The most reactive nucleophile in polar protic solvent aprotic solvent

Started by adharshni, April 22, 2020, 10:56:34 PM

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adharshni

April 22, 2020, 10:56:34 PM
How will F- be the most reactive nuclephile in polar aprotic solvent

uma

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April 25, 2020, 02:59:25 AM
Fluoride is a strong nucleophile in polar aprotic solvent due to two reasons
1) High electron density on F- due to a very small size.
2) Less interaction in polar aprotic solvents due to bulky groups around the positive charge which is on carbon atom bonded to EN atom.
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